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Innate immune responses in RNA viral infection
Qian Xu, Yuting Tang, Gang Huang
Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 333-346 doi: 10.1007/s11684-020-0776-7
Keywords: innate immune viral infection intercellular signaling metabolic changes epigenetic changes
A brief review of microRNA and its role in PRRSV infection and replication
Xuekun GUO,Wenhai FENG
Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2, Pages 114-120 doi: 10.15302/J-FASE-2014022
Keywords: porcine reproductive and respiratory syndrome virus (PRRSV) microRNA antiviral viral tropism
Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia
Frontiers of Medicine 2013, Volume 7, Issue 3, Pages 333-344 doi: 10.1007/s11684-013-0275-1
This study reports the first death caused by a novel avian influenza A (H7N9) virus in Zhejiang Province, China. The patient had chronic hepatitis B and history of exposure to poultry. The patient initially complained of diarrhea and influenza-like symptoms on March 7 and 14 respectively. The disease progressed to severe pneumonia, sustained hypoxia, and coagulation abnormalities. The patient died on March 27 because of respiratory failure, multiple organ failure, and disseminated intravascular coagulation without oseltamivir treatment. This H7N9 virus from Zhejiang is highly similar to isolates obtained from Shanghai, Jiangsu, Anhui, etc. Analysis of hemagglutinin, neuramidinase, and matrix genes indicated that the isolates share the same avian origin, have low virulence, and are sensitive to oseltamivir, but are resistant to adamantine. Only the isolate that caused the fatality exhibited substitution of Q226I in the HA gene, which indicates a potentially enhanced human affinity. The secondary transmission rate was 1.6% (2/125). Only two health workers presented with influenza-like symptoms, and they subsequently tested negative for H7N9 RNA. In conclusion, underlying disease, late diagnosis, and untimely antiviral treatment are possible high-risk factors for infections and death caused by the low-pathogenicity avian influenza A (H7N9). Person-to-person transmission of the H7N9 virus was not detected among close contacts, but such transmission should be investigated in the future. Expanding and enhancing surveillance will help in the early discovery and diagnosis of suspected cases, which will reduce the number of severe cases and deaths.
Keywords: avian influenza A (H7N9) virus epidemiology contacts person-to-person transmission
Analysis of antibiotic usage for viral community-acquired pneumonia in adults
Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li
Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 139-143 doi: 10.1007/s11684-019-0736-2
Keywords: adult antibiotic viral pneumonia
Correlation between viral load and liver cirrhosis in chronic hepatitis B patients
Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 271-276 doi: 10.1007/s11684-009-0054-1
Keywords: hepatitis B chronic viral load liver cirrhosis
Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 3, Pages 447-459 doi: 10.15302/J-FASE-2021399
Keywords: fennel and tobacco rotation infection behavior Phytophthora nicotianae reactive oxygen species
Clinical significance of human papilloma virus infection in the cervical lesions
Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA
Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 264-270 doi: 10.1007/s11684-010-0094-6
Keywords: cervical lesion high risk-human papilloma virus persistent infection loading dose cervical intraepithelial
Maliwan NACONSIE,Peng ZHANG
Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4, Pages 285-294 doi: 10.15302/J-FASE-2016119
Keywords: Manihot esculenta protein enhancement RNA interference transgenesis virus resistance
Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 449-461 doi: 10.1007/s11684-017-0589-5
Keywords: emerging and re-emerging viruses small-molecule inhibitor coronavirus Ebola virus Zika virus life cycle
Tangchun Wu
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 816-819 doi: 10.1007/s11684-020-0823-4
Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China
Rui Yu,Rong Fan,Jinlin Hou
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 135-144 doi: 10.1007/s11684-014-0331-5
Keywords: chronic hepatitis B epidemiology prevention treatment
Current recommendations of managing HBV infection in preconception or pregnancy
James S. Park,Calvin Pan
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 158-165 doi: 10.1007/s11684-014-0340-4
Keywords: antiviral therapy Caesarean section cirrhosis hepatitis B immunoprophylaxis mother-to-child transmission pregnancy prevention
Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients Article
Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak
Engineering 2023, Volume 26, Issue 7, Pages 54-62 doi: 10.1016/j.eng.2022.08.007
The essential role of immunoglobulin G (IgG) in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine 297 of the Fc domain that occur under such circumstances. These glycans impact the antibody stability, half-life, secretion, immunogenicity, and effector functions. Therefore, in this study, we analyzed and compared the total IgG glycome—at the level of individual glycan structures and derived glycosylation traits (sialylation, galactosylation, fucosylation, and bisecting N-acetylglucosamine (GlcNAc))—of 64 patients with influenza, 77 patients with coronavirus disease 2019 (COVID-19), and 56 healthy controls. Our study revealed a significant decrease in IgG galactosylation, sialylation, and bisecting GlcNAc (where the latter shows the most significant decrease) in deceased COVID-19 patients, whereas IgG fucosylation was increased. On the other hand, IgG galactosylation remained stable in influenza patients and COVID-19 survivors. IgG glycosylation in influenza patients was more time-dependent: In the first seven days of the disease, sialylation increased and fucosylation and bisecting GlcNAc decreased; in the next 21 days, sialylation decreased and fucosylation increased (while bisecting GlcNAc remained stable). The similarity of IgG glycosylation changes in COVID-19 survivors and influenza patients may be the consequence of an adequate immune response to enveloped viruses, while the observed changes in deceased COVID-19 patients may indicate its deviation.
Keywords: Influenza COVID-19 Viral infection Glycosylation Immunoglobulin G Pneumonia
Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 3, doi: 10.1007/s11783-020-1333-y
• Staff members were not colonised with MRSA.
Keywords: Antibiotic resistance Airborne MRSA Bioaerosols Healthcare-associated infections Healthcare worker Occupational health
Gynecologic infections seen in ThinPrep cytological test in Wuhan, China
Hang Zhou,Yao Jia,Jian Shen,Shaoshuai Wang,Xiong Li,Ru Yang,Kecheng Huang,Ting Hu,Fangxu Tang,Jin Zhou,Jingping Yuan,Lei Huang,Xun Tian,Zhilan Chen,Qinghua Zhang,Changyu Wang,Ling Xi,Dongrui Deng,Hui Wang,Ding Ma,Shuang Li
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 236-240 doi: 10.1007/s11684-014-0322-6
Keywords: ThinPrep cytological test human papillomavirus Candida infection Trichomonas infection bacterial infection
Title Author Date Type Operation
A brief review of microRNA and its role in PRRSV infection and replication
Xuekun GUO,Wenhai FENG
Journal Article
The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report
Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia
Journal Article
Analysis of antibiotic usage for viral community-acquired pneumonia in adults
Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li
Journal Article
Correlation between viral load and liver cirrhosis in chronic hepatitis B patients
Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,
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INTERFERENCE BY NON-HOST PLANT ROOTS AND ROOT EXUDATES IN THE INFECTION PROCESSES OF PHYTOPHTHORA NICOTIANAE
Journal Article
Clinical significance of human papilloma virus infection in the cervical lesions
Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA
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Transgenic technologies in cassava for nutritional improvement and viral disease resistance: a key strategy
Maliwan NACONSIE,Peng ZHANG
Journal Article
Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging
Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang
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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges
Tangchun Wu
Journal Article
Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China
Rui Yu,Rong Fan,Jinlin Hou
Journal Article
Current recommendations of managing HBV infection in preconception or pregnancy
James S. Park,Calvin Pan
Journal Article
Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients
Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak
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Occupational risk of exposure to methicillin-resistant (MRSA) and the quality of infection hygiene in
Journal Article
Gynecologic infections seen in ThinPrep cytological test in Wuhan, China
Hang Zhou,Yao Jia,Jian Shen,Shaoshuai Wang,Xiong Li,Ru Yang,Kecheng Huang,Ting Hu,Fangxu Tang,Jin Zhou,Jingping Yuan,Lei Huang,Xun Tian,Zhilan Chen,Qinghua Zhang,Changyu Wang,Ling Xi,Dongrui Deng,Hui Wang,Ding Ma,Shuang Li
Journal Article